毛雨诺
博士，助理研究员
邮箱：maoyunuo@sdu.edu.cn
个人主页：https://faculty.sdu.edu.cn/maoyunuo/zh_CN/index.htm
工作经历：
2022.11-至今
山东大学基础医学院系统生物医学系 助理研究员
教育经历：
2017.09-2022.07北京大学生命科学学院 博士研究生
2013.09-2017.07山东农业大学生命科学学院 本科
科研项目：
1、山东省自然科学基金青年项目（主持，2024.01-2026.12）
科研情况：
致力于整合疾病类器官模型和高精度单细胞组学测序技术，探究肿瘤分子靶向治疗的作用机制，开展高通量药物筛选、药效评估与转化医学研究。博士期间利用高精度单细胞转录组测序技术、单细胞甲基化组测序技术、单细胞多组学测序技术结合类器官模型解析生物发育和疾病等生物学机理。
发表论文：
1.Mao Y N*, Wang W*, Yang J W*, Zhou X, Lu Y Q, Gao J P, Wang X, Wen L, Fu W, Tang F C. Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids [J]. Protein Cell, 2023: pwad038.
2. R. Wang*, Y. Mao*, W. Wang*, X. Zhou*, W. Wang*, S. Gao, J. Li, L. Wen, W. Fu and F. Tang (2022). "Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysis." Genome Biol 23(1): 106.
3. R. Wang*, J. Li*, X. Zhou*, Y. Mao*, W. Wang*, S. Gao*, W. Wang, Y. Gao, K. Chen, S. Yu, X. Wu, L. Wen, W. Fu and F. Tang (2022). "Single-cell Genomic and Transcriptomic Landscapes of Primary and Metastatic Tumors in Colorectal Cancer." Genome Med: 14(1), 93.
4. F. Zhou*, R. Wang*, P. Yuan*, Y. Ren*, Y. Mao*, R. Li, Y. Lian, J. Li, L. Wen, L. Yan, J. Qiao and F. Tang (2019). "Reconstituting the transcriptome and DNA methylome landscapes of human implantation." Nature 572(7771): 660-664.
5. Y. Hu*, X. Wang*, B. Hu*, Y. Mao*, Y. Chen*, L. Yan, J. Yong, J. Dong, Y. Wei, W. Wang, L. Wen, J. Qiao and F. Tang (2019). "Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis." PLoS Biol 17(7): e3000365.
6. Y. Fu*, M. Yang*, H. Yu*, Y. Wang*, X. Wu*, J. Yong, Y. Mao, Y. Cui, X. Fan, L. Wen, J. Qiao and F. Tang (2021). "Heterogeneity of glial progenitor cells during the neurogenesis-to-gliogenesis switch in the developing human cerebral cortex." Cell Rep 34(9): 108788.
7. J. Li*, R. Wang*, X. Zhou*, W. Wang*, S. Gao*, Y. Mao, X. Wu, L. Guo, H. Liu, L. Wen, W. Fu and F. Tang (2020). "Genomic and transcriptomic profiling of carcinogenesis in patients with familial adenomatous polyposis." Gut 69(7): 1283-1293.
8. J. Dong*, Y. Hu*, X. Fan*, X. Wu*, Y. Mao, B. Hu, H. Guo, L. Wen and F. Tang (2018). "Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis." Genome Biol 19(1): 31.
