刘长安

博士，副研究员

山东省海外科技人才

系统生物医学系行政秘书

邮箱：changanliu@sdu.edu.cn

研究领域

 生物医学信息学、生物医学多组学大数据分析、消化系统疾病、神经退行性疾病等。

工作经历

• 2022年06月–今                  副研究员, 山东大学基础医学院系统生物医学系

• 2019年08月–2022年05月   博士后, 香港中文大学医学院消化系统疾病研究所消化疾病研究国家重点实验室                 

• 2017年10月–2018年07月   博士后, 美国德克萨斯大学休斯顿健康科学中心生物医学信息学院

• 2012年06月–2017年09月   助教助研, 美国休斯顿大学数学系  

教育经历

• 2013年08月–2017年05月   数学博士, 美国休斯顿大学数学系                                                                            

• 2011年08月–2013年08月   应用数学硕士, 美国休斯顿大学数学系                                                                              

• 2006年09月–2010年06月   信息与计算科学理学学士, 山东大学(威海)数学与统计学院                                                                                                                    

发表文章

*: co-first author

1、Liu Changan and Dai Zhong, Impact of Correlated Activity and STDP on Network Structure, Journal of Nonlinear Modeling and Analysis, 2023 5 (2): 203-227.

2、Kang X, Liu C, Ding Y, Ni Y, Ji F, Lau HCH, Jiang L, Sung JJ, Wong SH, Yu J. Roseburia intestinalis generated butyrate boosts anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8+ T cells. Gut. 2023 Nov;72(11):2112-2122.

3、Kang X, Ng SK, Liu C, Lin Y, Zhou Y, Kwong TNY, Ni Y, Lam TYT, Wu WKK, Wei H, Sung JJY, Yu J, Wong SH. Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice. EBioMedicine. 2023 Jul;93:104670.

4、Li Q, Chan H, Liu WX, Liu CA, Zhou Y, Huang D, Wang X, Li X, Xie C, Liu WY, Wang XS, Ng SK, Gou H, Zhao LY, Fong W, Jiang L, Lin Y, Zhao G, Bai F, Liu X, Chen H, Zhang L, Wong SH, Chan MTV, Wu WKK, Yu J. Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice. Cancer Cell. 2023 Aug 14;41(8):1450-1465.e8.

5、Wei W, Wong CC, Jia Z, Liu W, Liu C, Ji F, Pan Y, Wang F, Wang G, Zhao L, Chu ESH, Zhang X, Sung JJY, Yu J. Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid. Nat Microbiol. 2023 Aug;8(8):1534-1548.

6、Ding Y, Zhao L, Wang G, Shi Y, Guo G, Liu C, Chen Z, Coker OO, She J, Yu J. PacBio sequencing of human fecal samples uncovers the DNA methylation landscape of 22 673 gut phages. Nucleic Acids Res. 2023 Dec 11;51(22):12140-12149.

7、Changan Liu, Siu-Kin Ng, Yanqiang Ding, Yufeng Lin, Weixin Liu, Sunny Hei Wong, Joseph Jao-Yiu Sung, and Jun Yu, Meta-analysis of mucosal microbiota reveals universal microbial signatures and dysbiosis in gastric carcinogenesis, Oncogene, 2022 Jul;41(28):3599-3610.

8、Olabisi Oluwabukola Coker, Changan Liu*, William Ka Kei Wu, Sunny Hei Wong, Wei Jia, Joseph JY Sung and Jun Yu, Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers, Microbiome, 2022 Feb 21: 10(1):35.

9、Shuang Yu, Changan Liu*, Yingtong Hou, Jie Li, Zhuming Guo, Luyao Zhang, Sui Peng, Shubin Hong, Lixia Xu, Xiaoxing Li, Rengyun Liu, Shuwei Chen, Bin Li, Zongpeng Weng, Yanbing Li, Weiming Lv, Jun Yu, and Haipeng Xiao, Integrative metabolomic characterization identifies plasma metabolomic signature in the diagnosis of papillary thyroid cancer, Oncogene, 2022 Apr;41(17):2422-2430.

10、inkai Liu, Wei Geng, Hanyong Sun, Changan Liu, Fan Huang, Jie Cao, Lei Xia, Hongchuan Zhao, Jianning Zhai, Qing Li, Xiang Zhang, Ming Kuang, Shunli Shen, Qiang Xia, Vincent Wai-Sun Wong and Jun Yu, Integrative metabolomic characterisation identifies altered portal vein serum metabolome contributing to human hepatocellular carcinoma, Gut, 2021 Aug 3: gutjnl-2021-325189.

11、Liuyang Zhao, Yu Shi, Harry Cheuk-Hay Lau, Weixin Liu, Guangwen Luo, Guoping Wang, Changan Liu, Yasi Pan, Qiming Zhou, Yanqiang Ding, Joseph Jao-Yiu Sung and Jun Yu, Uncovering 1058 Novel Human Enteric DNA Viruses Through Deep Long-Read Third-Generation Sequencing and Their Clinical Impact, Gastroenterology, 2022 Jun 6: S0016-5085(22)00593-5.

12、Yufeng Lin, Harry Cheuk-Hay Lau, Yali Liu, Xing Kang, Yiwei Wang, Nick Lung-Ngai Ting, Thomas Ngai-Yeung Kwong, Jing Han, Weixin Liu, Changan Liu, Junjun She, Sunny Hei Wong, Joseph Jao-Yiu Sung and Jun Yu, Altered mycobiota signatures and enriched pathogenic Aspergillus rambellii are associated with colorectal cancer based on multi-cohort fecal metagenomic analyses, Gastroenterology, 2022 Jun 18: S0016-5085(22)00656-4.

13、Chuangen Li, Yong Wang, Dabin Liu, Chi Chun Wong, Olabisi O. Coker, Xiang Zhang, Changan Liu, Yunfei Zhou, Yali Liu, Wei Kang, Ka Fai To, Joseph Jao-Yiu Sung and Jun Yu, Squalene Epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis, Gut, 2022 Mar 1: gutjnl-2021-325851.

14、Xiaowu Bai, Hong Wei, Weixin Liu, Olabisi O. Coker, Hongyan Gou, Changan Liu, Liuyang Zhao, Chuangen Li, Yunfei Zhou, Guoping Wang, Wei Kang, Enders K.W. NG and Jun Yu, Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites, Gut, 2022 Apr 6: gutjnl-2021-325021.

15、Zhiwei Ji, Changan Liu, Weiling Zhao, Claudio Soto and Xiaobo Zhou, Multi-scale modeling for systematically understanding the key roles of microglia in AD development, Computers in Biology and Medicine, Vol. 133, (2021): 104374.

16、Changan Liu and Jun Yu, Genome-Wide Association Studies for Cerebrospinal Fluid Soluble TREM2 in Alzheimer’s Disease, Frontiers in Aging Neuroscience, Vol. 11, (2019): 297.

17、Changan Liu, Jacqueline Chyr, Weiling Zhao, Yungang Xu, Zhiwei Ji, Hua Tan, Claudio Soto, and Xiaobo Zhou, Genome-wide association and mechanistic studies indicate that immune response contributes to Alzheimer’s disease development, Frontiers in Genetics, Vol. 9, (2018): 410.

18、Changan Liu and Shutang Liu, The Formats of Julia Sets for Complex Dynamic Systems, Journal of Nonlinear Modeling and Analysis, Vol. 1, No. 4, (2019): 1-17.

19、Changan Liu, Qiuyue Zhao, Changquan Hu and Shutang Liu, Fractal characteristics of Heterocapsa Circularisquama and Prorocentrum Dentatum cells growth, International Journal of Biomathematics, Vol. 12, No. 08, (2019): 1950090.

20、Changan Liu and Miao Ouyang, 2D Random Approximation Method, Journal of Nonlinear Modeling and Analysis, Vol. 3, No. 3, (2021): 431-446.

21、Jiang Cuimei, Changan Liu, Shutang Liu, and Fangfang Zhang, Combination complex synchronization among three incommensurate fractional-order chaotic systems, Journal of Mathematics and Computer Science-JMCS, Vol. 16, No. 3, (2016): 308-323.

22、Ping Liu and Chang-an Liu, Linear generalized synchronization of spatial Julia sets, International Journal of Bifurcation and Chaos, Vol. 21, No.5 (2011): 1281-1291.

23、Zhang Yong-Ping, Sun Wei-Hua, and Liu Chang-An, Control and synchronization of second Julia sets, Chinese Physics B, Vol. 19, No. 5, (2010): 050512.

出版书籍：

• Shu Tang Liu, Yong Ping Zhang and Chang An Liu, Fractal Control and Its Application, Springer, Singapore (2020), ISBN: 978-981-15-5458-2.